INFLUENCE OF MOUSE GENOTYPE ON THE CHANGES IN BRAIN CYCLIC NUCLEOTIDE LEVELS INDUCED BY ACUTE ALCOHOL ADMINISTRATION

被引：12

作者：

CHURCH, AC ^{[1
]}

FELLER, D ^{[1
]}

机构：

[1] UNIV MISSOURI,DEPT BIOCHEM,COLUMBIA,MO 65212

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 03期

关键词：

Cyclic AMP; Cyclic nucleotides; Ethanol hypothermia; Ethanol narcosis; Psychopharmacogenetics;

D O I：

10.1016/0091-3057(79)90193-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Two mouse strains (C57BL/6By and BALB/cByJ) were found to differ widely in their sleep-time response to ethanol (3 g/kg), but showed no difference in their hypothermic response to the same ethanol dose. Comparison of brain cyclic nucleotide levels in the two strains revealed a strain difference in the brain cyclic AMP response to ethanol but no strain difference in the magnitude of the brain cyclic GMP change. Alcohol produced a significant drop in cerebellar cyclic GMP in both strains, and a decrease in cerebellar cyclic AMP in C57BL/6By mice. The cyclic AMP/cyclic GMP ratio increased following alcohol in the cerebellum of BALB/cByJ mice but not C57BL/6By mice. The results are discussed in terms of possible relationships between alcohol-induced changes in neurochemistry and behavior. © 1979.

引用

页码：335 / 338

页数：4

共 22 条

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