LACK OF BENEFIT OF ALLOPURINOL IN DUCHENNE DYSTROPHY

被引：37

作者：

MENDELL, JR

WIECHERS, DO

机构：

[1] OHIO STATE UNIV,COLL MED,DEPT MED NEUROL,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,COLL MED,DEPT PHYS MED & REHABIL,COLUMBUS,OH 43210

[3] OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210

来源：

MUSCLE & NERVE | 1979年 / 2卷 / 01期

关键词：

D O I：

10.1002/mus.880020108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A double‐blind, controlled study was conducted to assess the effects of allopurinol on Duchenne muscular dystrophy. Six patients—three treated with allopurinol and three given a placebo—were followed up for one year and were evaluated by functional and manual muscle testing as well as by determination of serum creatine kinase (CK) levels. Patients in both the allopurinol‐treated group and the placebo group deteriorated at varying rates without evidence of therapeutic benefit. To exclude the possibility of error attributable to small sample size, all six patients were treated with allopurinol for an additional eight‐week period. Muscle strength continued to deteriorate during this phase of the study. Copyright © 1979 Houghton Mifflin Professional Publishers

引用

页码：53 / 56

页数：4

共 6 条

[1]

BROOKE MICHAEL H., 1966, ARCH PHYS MED REHABIL, V47, P99

[2]

DUBOWITZ V, 1973, MUSCLE BIOPSY MODERN, P168

[3]

HENRY RJ, 1974, CLIN CHEM PRINCIPLES, P534

[4] SIGNIFICANCE OF CREATINE-PHOSPHOKINASE ISOENZYMES IN DUCHENNE DYSTROPHY [J].