ACUTE ORAL TOXICITY OF SODIUM-FLUORIDE AND MONOFLUOROPHOSPHATE SEPARATELY OR IN COMBINATION IN RATS

被引：11

作者：

WHITFORD, GM ^{[1
]}

BIRDSONGWHITFORD, NL ^{[1
]}

FINIDORI, C ^{[1
]}

机构：

[1] LABS GOUPIL SA,DEPT ODONTOSTOMATOL,CACHAN,FRANCE

来源：

CARIES RESEARCH | 1990年 / 24卷 / 02期

关键词：

Absorption; Acute toxicity; Bioavailability; Dentifrice; LD[!sub]50[!/sub; Plasma concentration;

D O I：

10.1159/000261252

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values. © 1990 S. Karger AG, Basel.

引用

页码：121 / 126

页数：6

共 21 条

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