THYROTROPIN-RELEASING-HORMONE-IMMUNOREACTIVE INNERVATION OF THYROTROPIN-RELEASING-HORMONE-TUBEROINFUNDIBULAR NEURONS IN RAT HYPOTHALAMUS - ANATOMICAL BASIS TO SUGGEST ULTRASHORT FEEDBACK-REGULATION

被引:17
作者
TONI, R
JACKSON, IMD
LECHAN, RM
机构
[1] NEW ENGLAND MED CTR HOSP, DEPT MED,DIV ENDOCRINE,BOX 268,750 WASHINGTON ST, BOSTON, MA 02111 USA
[2] TUFTS UNIV, SCH MED, BOSTON, MA 02111 USA
[3] BROWN UNIV, RHODE ISL HOSP, DIV ENDOCRINOL, PROVIDENCE, RI 02903 USA
关键词
Hypothalamus; Thyrotropin-releasing hormone; Ultrashort feedback;
D O I
10.1159/000125623
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyrotropin-releasing-hormone (TRH)-synthesizing neurons in the medial and periventricular parvocellular subdivisions of the rat hypothalamic paraventricular nucleus (PVN) are involved in regulation of the anterior pituitary. Since ultrashort feedback regulation of TRH in the hypothalamus has been suggested by physiological studies, we sought to identify the presence of TRH synaptic contacts containing TRH on TRH tuberoinfundibular neurons in the PVN. An immunocytochemical study was performed at light- and electron-microscopic levels using antiserum directed to the N-terminal cryptic sequence of the TRH precursor, prepro TRH 25-50. At the light-microscopic level, contacts between TRH immunoreactive (IR) fibers and the perikarya and processes of TRH-1R neurons were observed in medial and periventricular subdivisions of the PVN. At the ultrastructural level, TRH-neurons appeared either tightly juxtaposed to TRH-immunopositive perikarya and dendrites or to establish axodendritic and axosomatic contacts suggestive of synaptic associations. These data provide a morphologic basis to support a neuroendocrine role for TRH or processed forms of pro TRH in the PVN and in particular suggest their involvement as neuromodulators in an ultrashort feedback regulation of TRH tuberoinfundibular neurons. © 1990 S. Karger AG, Basel.
引用
收藏
页码:422 / 428
页数:7
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