EFFECT OF NALOXONE ON ANALGESIA INDUCED BY FOOD-DEPRIVATION

被引：96

作者：

MCGIVERN, R

BERKA, C

BERNTSON, GG

WALKER, JM

SANDMAN, CA

机构：

[1] The Ohio State University, Department of Psychology, Columbus, OH 43212

来源：

LIFE SCIENCES | 1979年 / 25卷 / 10期

关键词：

D O I：

10.1016/0024-3205(79)90547-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Naloxone (4 mg/kg) or saline was administered to animals under food deprived and non-deprived conditions prior to testing pain sensitivity in the tail flick test. Food deprived animals exhibited significantly elevated latencies in comparison to latencies observed under non-deprived conditions. This analgesia was diminished by treatment with the opiate receptor antagonist, naloxone. These findings suggest that analgesia induced by food deprivation is mediated in part by opiate receptor systems. © 1979.

引用

页码：885 / 888

页数：4

共 17 条

[1]

AKIL H, 1976, OPIATES ENDOGENOUS O

[2] ENDOGENOUS OPIOID LIGANDS MAY MEDIATE STRESS-INDUCED CHANGES IN AFFECTIVE PROPERTIES OF PAIN RELATED BEHAVIOR IN RATS [J].