PLASMODIUM-FALCIPARUM - THE EFFECT OF PH AND CA2+ CONCENTRATION ON THE INVITRO CYTOADHERENCE OF INFECTED ERYTHROCYTES TO AMELANOTIC MELANOMA-CELLS

被引：27

作者：

CRANDALL, I

SMITH, H

SHERMAN, IW

机构：

[1] University of California, Riverside, Department of Biology, Riverside

来源：

EXPERIMENTAL PARASITOLOGY | 1991年 / 73卷 / 03期

关键词：

Calcium; Cytoadherence; pH; Plasmodium falciparum;

D O I：

10.1016/0014-4894(91)90108-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Cytoadherence of Plasmodium falciparum-infected erythrocytes to amelanotic melanoma cells was pH dependent; increased adherence was observed in the pH range of 6.1 to 6.8 and was greatest between pH 6.6 and 6.8. Ca2+ promoted Cytoadherence, but at higher concentrations (40-50 mM) than is usually the case for cell-cell adhesion. The effects of pH and Ca2+ were interdependent-the pH optimum of Cytoadherence was altered by the Ca2+ concentration in the medium. The adherent properties of several P. falciparum lines (including a knobless cytoadherent line) under varying pH and Ca2+ concentrations were similar. © 1991.

引用

页码：362 / 368

页数：7

共 26 条

[1] A HUMAN 88-KD MEMBRANE GLYCOPROTEIN (CD36) FUNCTIONS INVITRO AS A RECEPTOR FOR A CYTOADHERENCE LIGAND ON PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES [J].