BENEFICIAL EFFECT OF ISRADIPINE ON THE DEVELOPMENT OF LEFT-VENTRICULAR HYPERTROPHY IN MILD HYPERTENSION

被引：6

作者：

MEHLSEN, J

GLEERUP, G

HAEDERSDAL, C

WINTHER, K

机构：

[1] Department of Clinical Chemistry, Glostrup Hospital, Copenhagen

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 03期

关键词：

LEFT VENTRICULAR HYPERTROPHY; CALCIUM ANTAGONISTS; BETA-BLOCKERS; HYPERTENSION; EXERCISE CAPACITY;

D O I：

10.1093/ajh/6.3.95S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The objective of this study was to analyze the long-term hemodynamic effects of the calcium antagonist isradipine in mild hypertension compared with those of the beta1-selective adrenoceptor antagonist atenolol, focusing in particular on the development of cardiac hypertrophy. Ten male patients with mild essential hypertension were entered into a double-blind crossover study. Examinations were carried out after 2 weeks of placebo run-in, and after 6 and 12 months of active treatment. Mean resting blood pressure was reduced from 115 +/- 12 mm Hg to 106 +/- 12 mm Hg with atenolol, and to 107 +/- 8 mm Hg with isradipine. The increase in the product of heart rate times blood pressure was significantly greater during isradipine treatment, as was the maximum exercise capacity. Left ventricular mass was increased from 228 +/- 36 g to 305 +/- 68 g with atenolol whereas it remained unchanged with isradipine (254 +/- 55 g). The results indicate that antihypertensive treatment with isradipine as monotherapy may prevent the development of left ventricular hypertrophy whereas treatment with atenolol as monotherapy does not appear to offer this possibility.

引用

页码：S95 / S97

页数：3

共 6 条

[1]

Dahlof B., Pennert K., Hansson L., Reversal of left ventricular hypertrophy in hypertensive patients: A meta-analysis of 109 treatment studies, Am J Hypertens, 5, pp. 95-110, (1992)

[2]

Bielen E.C., Fagard R.H., Lijnen P.J., Et al., Comparison of the effects of isradipine and lisinopril on left ventricular structure and function in essential hypertension, Am J Cardiol, 62, pp. 1200-1206, (1992)

[3]

Devereux R.B., Alonso D.R., Lutas E.M., Et al., Echocardiographie, Am J Cardiol, 57, (1986)

[4]

Saragoca M.A., Portela J.E., Abreu P., Et al., Regression of left ventricular hypertrophy in the short-term treatment of hypertension with isradipine, Am J Hypertens, 4, pp. 188S-190S, (1991)

[5]

Saragoca M.A., Portela J.E., Abreu P., Et al., Reversal of left ventricular hypertrophy following treatment of hypertension with isradipine, J Cardiovasc Pharmacol, 18, pp. S28-S30, (1991)

[6]

Carr A.A., Prisant L.M., The new calcium antagonist isradipine: Effect on blood pressure and the left ventricle in black hypertensive patients, Am J Hypertens, 3, pp. 8-15, (1990)

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