METABOLISM OF DIBROMOBIPHENYL, TRIBROMOBIPHENYL AND TETRABROMOBIPHENYL BY HEPATIC MICROSOMES ISOLATED FROM CONTROL ANIMALS AND ANIMALS TREATED WITH AROCLOR-1254, A COMMERCIAL MIXTURE OF POLYCHLORINATED-BIPHENYLS (PCBS)

被引：5

作者：

BORLAKOGLU, JT

WILKINS, JPG

机构：

[1] UNIV READING,SCH ANIM & MICROBIAL SCI,DEPT BIOCHEM & PHYSL,READING RG6 2AJ,BERKS,ENGLAND

[2] MAFF,HARPENDEN LABS,HARPENDEN AL5 2BD,HERTS,ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 105卷 / 01期

关键词：

D O I：

10.1016/0742-8413(93)90065-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The metabolism of di-, tri- and tetrabromobiphenyls (PBBs) by hepatic microsomes isolated from control animals and animals treated with Arochlor 1254 was studied. 2. Hepatic microsomes isolated fom control rats expressed higher rates of oxidations than avians 3. Treatment of rats and pigeons with Arochlor 1254 induced cytochrome P450 dependent monooxygenases leading to an increased regioselective metabolism of PBB isomer and congeneres. 4. There was an inverse relationship between the degree of halosubstitution and microsomal oxidation. Meta-para carbon atoms free of halosubstitution were the preferred side for oxidation.

引用

收藏

页码：107 / 112

页数：6

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