MECHANISMS OF ACTION OF ANTIPHOSPHOLIPID ANTIBODIES IN THE ANTIPHOSPHOLIPID SYNDROME

被引：25

作者：

ARON, AL

GHARAVI, AE

SHOENFELD, Y

机构：

[1] LOUISIANA STATE UNIV,MED CTR,DEPT MED,RHEUMATOL SECT,NEW ORLEANS,LA 70112

[2] CHAIM SHEBA MED CTR,DEPT MED B,IL-52621 TEL HASHOMER,ISRAEL

[3] TEL AVIV UNIV,SACKLER SCH MED,RAMAT GAN,ISRAEL

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 106卷 / 01期

关键词：

ANTIPHOSPHOLIPID ANTIBODY SYNDROME; SLE; THROMBOSIS; PLATELETS; FETAL LOSS; ANTICARDIOLIPIN ANTIBODY; LUPUS ANTICOAGULANT; BETA(2)-GLYCOPROTEIN I; ANTITHROMBIN III; PROTEIN C;

D O I：

10.1159/000236883

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cells, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal development.

引用

页码：8 / 12

页数：5

共 48 条

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