ISOLATION OF SOME IMMUNOSUPPRESSIVE COMPONENTS FROM AN ASCOMYCETE, GELASINOSPORA MULTIFORIS

被引：21

作者：

FUJIMOTO, H ^{[1
]}

SATOH, Y ^{[1
]}

NAKAYAMA, M ^{[1
]}

TAKAYAMA, T ^{[1
]}

YAMAZAKI, M ^{[1
]}

机构：

[1] CHIBA UNIV, FAC PHARMACEUT SCI, INAGE KU, CHIBA 263, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 04期

关键词：

FUNGAL METABOLITE; ASCOMYCETE; GELASINOSPORA MULTIFORIS; IMMUNOSUPPRESSANT; MULTIFORISIN; ALPHA-PYRONE; (2H-PYRAN-2-ONE);

D O I：

10.1248/cpb.43.547

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new components, named multiforisins A, B, C, D, and E, with immunosuppressive activity were isolated from an Ascomycete, Gelasinospora multiforis. Multiforisin A, the main immunosuppressive principle of this fungus, was deduced to be 5-formyl-3-(hydroxymethyl)-4-methoxy-6-(1E-propenyl)-alpha-pyrone. Multiforisins B, C, D, and E were also deduced to be a-pyrone derivatives related to multiforisin A. The IC50 values of multiforisins A, B, C, D, E, and dihydro multiforisin A were evaluated against proliferation of mouse spleen lymphocytes stimulated with concanavalin A and lipopolysaccharide.

引用

页码：547 / 552

页数：6

共 9 条

[1]

Fujimoto H., 1988, Proceedings of the Japanese Association of Mycotoxicology, P15

[2]

FUJIMOTO H, 1994, CHEM PHARM BULL, V42, P694, DOI 10.1248/cpb.42.694

[3]

FUJIMOTO H, 1993, CHEM PHARM BULL, V41, P654, DOI 10.1248/cpb.41.654

[4] STRUCTURE OF ISLANDIC ACID, A NEW METABOLITE FROM PENICILLIUM-ISLANDICUM SOPP [J].

FUJIMOTO, Y ;

TSUNODA, H ;

UZAWA, J ;

TATSUNO, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (01) :83-84

[5]

Horie Y., 1974, T MYCOL SOC JAPAN, V15, P196

[6]

ISHII H, 1977, TETRAHEDRON LETT, P1227, DOI 10.1016/S0040-4039(01)92982-X

[7] METABOLITES OF PYRENOMYCETES .6. BIOGENESIS AND REVISED STRUCTURE OF ROSELLISIN - STRUCTURE OF ROSELLISIN ALDEHYDE [J].

NAIR, MSR .

PHYTOCHEMISTRY, 1976, 15 (06) :1090-1091

[8]

NAIR MSR, 1975, TETRAHEDRON LETT, P3517

[9]

Tori K, 1980, KAGAKU NO RYOIKI ZOK, V125, P221

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