GONADOTROPIN-RELEASING-HORMONE AGONIST (BUSERELIN) IN THE TREATMENT OF ENDOMETRIOSIS - CHANGES IN THE EXTENT OF THE DISEASE AND IN CA-125 SERUM LEVELS AFTER 6-MONTH THERAPY

被引：9

作者：

MARANA, R

MUZII, L

MUSCATELLO, P

LANZONE, A

CARUSO, A

DELLACQUA, S

MANCUSO, S

机构：

[1] Department of Obstetrics and Gynaecology, Catholic University of the Sacred Heart, Rome, 00168, Largo F. Vito l

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1990年 / 97卷 / 11期

关键词：

D O I：

10.1111/j.1471-0528.1990.tb02474.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Summary. Twenty‐two women with endometriosis were treated with the luteinizing hormone‐releasing hormone (LHRH) agonist buserelin for 6 months. At second‐look laparoscopy the mean score of endometriosis had decreased from 23.1 (SD 17.0) to 17.2 (SD 20.2) (P<0.05). CA 125 serum levels decreased from 38.4 (SD 32.2) U/ml at diagnosis to 15.5 (SD 7.0) at second look (P<0.005). CA 125 levels correlated at diagnosis with total score of endometriosis (P<0.05) and with active score of endometriosts (P<0.05), but not with the adhesion score. CA 125 levels were not correlated with endometriosis scores at second look laparoscopy, thus suggesting that mechanisms other than the change in the extent of the disease may be involved in the CA 125 decrease during therapy. CA 125 levels may therefore not be a reliable indicator for monitoring the efficacy of LHRH agonist treatment of endometriosis. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1016 / 1019

页数：4

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