FUNCTIONAL-DEVELOPMENT OF DOPAMINE RECEPTORS IN THE RAT FOREBRAIN

被引:12
作者
ORMOND, DL
VANHARTESVELDT, C
机构
[1] Department of Psychology, University of Florida, Gainesville
关键词
Cannulations; Development; Dopamine receptors; Mesolimbic; Rotational behavior; Striatum;
D O I
10.1016/0091-3057(79)90057-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Dopamine (DA) was injected unilaterally into the dorsal caudate-putamen (D-CPU), ventral caudate-putamen (V-CPU), piriform cortex (PIR), olfactory tubercle (OTU) and frontal cortex (FC) of two day old rats and rotational behavior observed. Injection of DA into D-CPU, PIR, and OTU produced a contralateral postural deviation which differed significantly from the ipsilateral deviation produced by control injections. Only DA injections into PIR and OTU produced contralateral turning differing significantly from the effects of control injections. These results suggest that the DA receptors in D-CPU, PIR, and OTU involved in rotational behavior are functionally mature at two days of age and that the two components of rotation, postural deviation (direction) and turning (locomotion), involve different neural systems at this age. The developing rat is suggested as a valuable tool for understanding the neural circuitry and pharmacology of rotational behavior. © 1979.
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页码:855 / 860
页数:6
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