CAFFEINE SECRETION INTO BREAST-MILK

被引：97

作者：

TYRALA, EE

DODSON, WE

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROL SURG NEUROL,ST LOUIS,MO 63130

[2] WASHINGTON UNIV,SCH MED,EDWARD MALLINCKRODT DEPT PEDIAT,ST LOUIS,MO 63130

[3] ST LOUIS CHILDRENS HOSP,DIV NEONATAL,ST LOUIS,MO 63110

[4] ST LOUIS CHILDRENS HOSP,DIV PEDIAT NEUROL,ST LOUIS,MO 63110

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1979年 / 54卷 / 10期

关键词：

D O I：

10.1136/adc.54.10.787

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Serum and milk concentrations of caffeine were measured in 5 breast-feeding mothers after a standardised oral dose of caffeine. Peak concentrations of caffeine in serum and milk were attained 60 minutes later. Binding of caffeine by constituents of serum and breast milk was low (25 and 3·2% respectively). In breast milk, caffeine binding is associated with the cream layer, and correlates with the butter fat content. Caffeine does not diffuse freely into breast milk and concentrations in milk are lower than in maternal serum.

引用

页码：787 / 789

页数：3

共 8 条

[1]

ABRAMOWITZ M, 1977, MED LETT, V19, P65

[2] EFFICACY OF CAFFEINE IN TREATMENT OF APNEA IN LOW-BIRTH-WEIGHT INFANT [J].