ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF DEGENERATE NEURITE-BEARING GHOST TANGLES

被引：27

作者：

IKEDA, K

HAGA, C

OYANAGI, S

IRITANI, S

KOSAKA, K

机构：

[1] TOKYO METROPOLITAN MATSUZAWA HOSP,SETAGAYA KU,TOKYO,JAPAN

[2] PSYCHIAT RES INST TOKYO,DEPT ULTRASTRUCT,TOKYO 156,JAPAN

[3] YOKOHAMA CITY UNIV,SCH MED,DEPT PSYCHIAT & NEUROL,YOKOHAMA,KANAGAWA 232,JAPAN

来源：

JOURNAL OF NEUROLOGY | 1992年 / 239卷 / 04期

关键词：

GHOST TANGLES; DEGENERATE NEURITES; ASTROCYTES; SENILE PLAQUES; ULTRASTRUCTURE;

D O I：

10.1007/BF00839138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Some ghost tangles in the brains of Alzheimer patients were accompanied by many small argyrophilic structures which were electron microscopically confirmed to be degenerate neurites. In these ghost tangles. roughly dispersed 15 nm straight and occasional twisted tubules were penetrated by proliferated astrocytic processes. Immunohistochemically, these ghost tangles lost immunoreactivities to anti-NFT, -tau and -ubiquitin antibodies, but were thioflavine-S fluorescent, though antigenicity to beta-protein was not proved. This similarity in composition of degenerate neurite-bearing ghost tangles to senile plagues might be induced by the amyloid nature of tubules, which probably provokes the reaction of neuropils.

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页码：191 / 194

页数：4

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