EFFECT OF INTRAVENOUSLY INFUSED EICOSAPENTAENOIC ACID ON THE LEUKOTRIENE GENERATION IN PATIENTS WITH ACTIVE CROHNS-DISEASE

被引:43
作者
IKEHATA, A
HIWATASHI, N
KINOUCHI, Y
YAMAZAKI, H
KUMAGAI, Y
ITO, K
KAYABA, Y
TOYOTA, T
机构
[1] Third Dept. of Internal Medicine, Tohoku University School of Medicine, Aoba-ku, Sendai 980
关键词
FISH OIL; EICOSAPENTAENOIC ACID; CROHNS DISEASE; LEUKOTRIENE-B4; LEUKOTRIENE-B5;
D O I
10.1093/ajcn/56.5.938
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Ten patients with active Crohn's disease who have been managed with parenteral-nutrition therapy were administered a lipid emulsion either with [containing 0.6 g eicosapentaenoic acid (EPA)] or without fish oil for 2 wk. We isolated polymorphonuclear leukocytes (PMNLs) from the patients before and after this treatment and measured the amounts of leukotriene B4 (LTB4) and leukotriene B-5 (LTB5) generated by activated PMNLs by reversed-phase HPLC. The LTB5 generation in active Crohn's disease before this treatment was significantly lower than in healthy control subjects. The amount of LTB5 and the LTB5-LTB4 ratio increased significantly after fish-oil supplementation. The difference with LTB4 was not statistically significant. We have shown that daily intravenous administration of 0.6 g EPA influenced the generation of leukotrienes in active Crohn's disease even after short-term treatment. Further investigations are necessary to clarify the correlation between EPA and clinical improvement in Crohn's disease.
引用
收藏
页码:938 / 942
页数:5
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