FREE-RADICAL ANNELATION IN THE SYNTHESIS OF BICYCLIC BETA-LACTAMS .7. A ONE-POT, 4-STEP, SEQUENTIAL REACTION

被引：53

作者：

BOSCH, E ^{[1
]}

BACHI, MD ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT ORGAN CHEM,IL-76100 REHOVOT,ISRAEL

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 21期

关键词：

D O I：

10.1021/jo00073a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nonfused, alkynyl-beta-lactams 10 and 18 react with n-Bu3SnH to give tert-butyl carbaceph-2-em-4-carboxylate (11) and methyl 1-oxahomoceph-3-em-5-carboxylate (19), respectively, in a four-step, sequential radical reaction involving homolytic intermolecular addition, intramolecular hydrogen atom transfer, endo-intramolecular addition, and beta-elimination.

引用

页码：5581 / 5582

页数：2

共 23 条

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