THE EFFECT OF OXYTOCIN ON FEEDING, DRINKING, AND MALE COPULATORY-BEHAVIOR IS NOT DIMINISHED BY NEONATAL MONOSODIUM GLUTAMATE

被引：3

作者：

ARLETTI, R ^{[1
]}

BENELLI, A ^{[1
]}

MAZZAFERRO, M ^{[1
]}

CALZA, L ^{[1
]}

GIARDINO, L ^{[1
]}

BERTOLINI, A ^{[1
]}

机构：

[1] HESPERIA HOSP,PATHOPHYSIOL CTR NERVOUS SYST,I-41100 MODENA,ITALY

来源：

HORMONES AND BEHAVIOR | 1993年 / 27卷 / 04期

关键词：

D O I：

10.1006/hbeh.1993.1036

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of oxytocin on feeding, drinking, and male copulatory behavior was studied in rats neonatally injected with monosodium glutamate (MSG), a treatment that destroys neuronal perikarya of the arcuate nucleus and depletes the brain of proopiomelanocortin-derived peptides (melanocortins, endorphins). Both oxytocin-induced inhibition of feeding (1 and 10 μg/rat ICV and 150 μg/rat IP) and drinking (75 and 150 μg/rat IP) and oxytocin-induced improvement of male copulatory behavior (200 ng/rat IP) were either unaffected or in fact increased by neonatal MSG treatment. These data suggest that oxytocin neither inhibits feeding and drinking nor improves male sexual behavior through the release of melanocortin peptide(s) in the brain. © 1993 by Academic Press, Inc.

引用

页码：499 / 510

页数：12

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