ENANTIORETENTIVE ALKYLATION OF OXAZOLIDINONE ALUMINUM ENOLATES WITH EPOXIDES - PREPARATION OF UNCODED HOMOSERINE ANALOGS

被引：14

作者：

SMITH, AB ^{[1
]}

PASTERNAK, A ^{[1
]}

YOKOYAMA, A ^{[1
]}

HIRSCHMANN, R ^{[1
]}

机构：

[1] UNIV PENN,MONELL CHEM SENSES CTR,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(94)88404-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alkylation of Karady/Seebach oxazolidinone enolates with epoxides, promoted by 2.1 equivalents of diethylaluminum chloride, furnishes ring-opened adducts in moderate-to-good yields with high diastereoselectivity. The method provides an effective approach to uncoded homoserine analogs and expands the utility of readily available oxazolidinones in asymmetric synthesis.

引用

页码：8977 / 8980

页数：4

共 14 条

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