CATHEPSIN-D GENERATES GAMMA-ENDORPHIN FROM BETA-ENDORPHIN

被引：45

作者：

GRAF, L ^{[1
]}

KENESSEY, A ^{[1
]}

PATTHY, A ^{[1
]}

GRYNBAUM, A ^{[1
]}

MARKS, N ^{[1
]}

LAJTHA, A ^{[1
]}

机构：

[1] INST NEUROCHEM,NEW YORK,NY 10035

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 193卷 / 01期

关键词：

D O I：

10.1016/0003-9861(79)90012-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A crude extract of porcine anterior pituitary was found to contain endopeptidase activity that splits the Leu77-Phe78 peptide bond of β-lipotropin in a pH range 3.0-7.0. The specificity and susceptibility to pepstatin of pituitary extract were the same as those of cathepsin D (E.C. 3.4.23.5) isolated from calf brain by affinity chromatography. Cathepsin D was shown to split the same Leu-Phe peptide bond of β-endorphin, leading to the formation of γ-endorphin. Based on the above data it is suggested that cathepsin D is a major factor in the generation of endorphins of intermediate size. © 1979.

引用

页码：101 / 109

页数：9

共 30 条

[1] GAMMA-ENDORPHIN, ALPHA-ENDORPHIN AND MET-ENKEPHALIN ARE FORMED EXTRACELLULARLY FROM LIPOTROPIN-C FRAGMENT [J].