EFFECT OF HEART-RATE ON DOPPLER MEASUREMENTS OF RESISTIVE INDEX IN RENAL-ARTERIES

The effect of heart rate on Doppler measurements of the resistive index (RI) in renal arteries was studied in eight patients by varying paced heart rate to eliminate intrinsic and extrinsic factors influencing renal vascular resistance. A Doppler spectrum was obtained in renal segmental arteries. The RI was calculated at increasing heart rates from 70 to 120 beats per minute. There was a statistically significant decrease in RI with increasing heart rate (heart rate of 70: RI = 0.7 ± 0.06; heart rate of 120: RI = 0.57 ± 0.06; P<.001), while blood pressure and cardiac output remained constant. To overcome this source of variance, the observed RI can be corrected for heart rate by using the following regression equation. For a heart rate of 80 beats per minute, corrected RI = observed RI - 0.0026(80 - observed heart rate). In interpreting the RI in renal allograft examinations, the actual heart rate of a patient must be taken into account. However, the clinical significance of standardizing the RI for heart rate requires further investigation.