DISSOLUTION PROFILES OF MESALAZINE FORMULATIONS INVITRO

被引：27

作者：

STOLK, LML ^{[1
]}

RIETBROEK, R ^{[1
]}

WILTINK, EH ^{[1
]}

TUKKER, JJ ^{[1
]}

机构：

[1] STATE UNIV UTRECHT,FAC PHARM,DEPT MAKROMOLEK CHEM,3511 GH UTRECHT,NETHERLANDS

来源：

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION | 1990年 / 12卷 / 05期

关键词：

Dissolution; Mesalazine; Tablets; controlled release;

D O I：

10.1007/BF01980047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In vitro dissolution profiles of three controlled-release mesalazine formulations were determined at pH 1.0, 6.0 and 7.5. A closed-column type dissolution apparatus was used. A reproducible gradual dissolution profile was seen for Pentasa® at all pH values. Dissolution starts immediately and is complete after 20 h. Dissolution profiles at pH 1 and pH 7.5 are much alike and dissolution is faster than at pH 6. The behaviour of Asacol® at different pH values corresponds with the expectations: no release at pH 6 and pH 1, fast release at pH 7.5. Dissolution starts after 1 h and is complete after 3 h. Mesalazine release from Salofalk® tablets at pH 7.5 and pH 6.0 starts after 2 and 3 h, respectively, and is complete after 5 and 10 h. However, after a long lag-time (10 h) mesalazine is also released from Salofalksu® tablets at pH 1 and dissolution is complete after 23 h. © 1990 Royal Dutch Association for Advancement of Pharmacy.

引用

页码：200 / 204

页数：5

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