INTERLEUKIN-6 STIMULATES PROSTAGLANDIN PRODUCTION BY HUMAN AMNION AND DECIDUAL CELLS

被引：190

作者：

MITCHELL, MD

DUDLEY, DJ

EDWIN, SS

SCHILLER, SL

机构：

[1] Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 01期

关键词：

INTERLEUKIN-6; PROSTAGLANDIN BIOSYNTHESIS; AMNION; DECIDUA; LABOR;

D O I：

10.1016/0014-2999(91)90090-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid for women with intrauterine infections and preterm labor. Hence, interleukin-6 may contribute to the mechanism of preterm labor under these conditions.

引用

页码：189 / 191

页数：3

共 8 条

[1]

LIECHTY K, IN PRESS PED RES

[2]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[3] PROSTAGLANDIN BIOSYNTHESIS BY HUMAN DECIDUAL CELLS - EFFECTS OF INFLAMMATORY MEDIATORS [J].

MITCHELL, MD ;

EDWIN, S ;

ROMERO, RJ .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1990, 41 (01) :35-38

[4]

OKITA JR, 1983, IN VITRO CELL DEV B, V19, P117

[5]

ROMERO R, 1988, SEMIN PERINATOL, V12, P262

[6] INTERLEUKIN-1 STIMULATES PROSTAGLANDIN BIOSYNTHESIS BY HUMAN AMNION [J].

ROMERO, R ;

DURUM, S ;

DINARELLO, CA ;

OYARZUN, E ;

HOBBINS, JC ;

MITCHELL, MD .

PROSTAGLANDINS, 1989, 37 (01) :13-22

[7] AMNIOTIC-FLUID INTERLEUKIN-6 IN PRETERM LABOR - ASSOCIATION WITH INFECTION [J].

ROMERO, R ;

AVILA, C ;

SANTHANAM, U ;

SEHGAL, PB .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1392-1400

[8]

VANDENBERG BJ, 1984, PERINATAL EPIDEMIOLO, P69

← 1 →