BETA-BLOCKADE DURING WHOLE-BODY HYPERTHERMIA - A TOXICITY STUDY IN THE DOG

被引：4

作者：

ROBINS, H

HUGANDER, A

BESOZZI, M

SCHMITT, CL

MARTIN, PA

ZAGER, LV

GROSSMAN, J

机构：

[1] UNIV WISCONSIN,SCH VET MED,CTR CLIN CANC,CTR CLIN SCI,DEPT MED,MADISON,WI 53792

[2] UNIV WISCONSIN,SCH VET MED,CTR CLIN CANC,CTR CLIN SCI,DEPT MED SCI,MADISON,WI 53792

来源：

INTERNATIONAL JOURNAL OF HYPERTHERMIA | 1991年 / 7卷 / 02期

关键词：

BETA-BLOCKADE; CARDIOVASCULAR; DOG; RADIANT HEAT; WHOLE-BODY HYPERTHERMIA;

D O I：

10.3109/02656739109004995

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A radiant heat device (RHD) for whole-body hyperthermia (WBH) has been safely and effectively used with a dog model. The cardiovascular changes which occur in the dog during WBH-including heart rate, blood pressure, cardiac output, stroke volume and ejection fraction-agree qualitatively and quantitatively with changes observed in previous WBH-RHD studies done in pigs and humans. We elected to study the effect of propanolol in dogs during WBH in order to evaluate this drug's potential use in human cancer patients who are ineligible for WBH because of coronary artery disease. This report details cardiovascular changes which occur with beta-blockade during 42-degrees-C WBH in the dog. Our results show that the level of beta-blockade needed to control heart rate during WBH produces acute cardiovascular decompensation.

引用

页码：263 / 270

页数：8

共 13 条

[1] WHOLE-BODY HYPERTHERMIA - PHASE-I TRIAL OF A POTENTIAL ADJUVANT TO CHEMOTHERAPY [J].