AN ALTERNATIVE COMPUTER-MODEL OF THE 3-DIMENSIONAL STRUCTURES OF MICROCYSTIN-LR AND NODULARIN RATIONALIZING THEIR INTERACTIONS WITH PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A

被引：21

作者：

TAYLOR, C

QUINN, RJ

MCCULLOCH, R

NISHIWAKIMATSUSHIMA, R

FUJIKI, H

机构：

[1] GRIFFITH UNIV,SCH SCI,NATHAN,QLD 4111,AUSTRALIA

[2] GRIFFITH UNIV,SCH SCI,NATHAN,QLD 4111,AUSTRALIA

[3] NATL CANC CTR,RES INST,DIV CANC PREVENT,CHUO KU,TOKYO 104,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)80204-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 3-dimensional structures of two cyclic peptides of the okadaic acid class of protein phosphatase inhibitors were found to have the same orientation of (2S,3S,8S,9S) 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E),6(E)-dienoic acid (Adda) with respect to both peptide rings. These results are consistent with these two compounds inhibiting protein phosphatase 1 and 2A activity with almost the same specific activity.

引用

页码：299 / 302

页数：4

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