TEMPERATURE-DEPENDENCE OF MOLAR VOLUME AND ADIABATIC COMPRESSIBILITY OF AQUEOUS-SOLUTIONS OF AN AMPHIPHILIC PHENOTHIAZINE DRUG

被引：26

作者：

ATTWOOD, D ^{[1
]}

MOSQUERA, V ^{[1
]}

REY, C ^{[1
]}

GARCIA, M ^{[1
]}

机构：

[1] UNIV SANTIAGO DE COMPOSTELA,FAC FIS,DEPT FIS MAT CONDENSADA,SANTIAGO,SPAIN

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 1991年 / 147卷 / 02期

关键词：

D O I：

10.1016/0021-9797(91)90163-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The apparent molar volume and adiabatic compressibility of aqueous solutions of the amphiphilic phenothiazine drug chlorpromazine have been determined from measurements of density and ultrasound velocity over the temperature range 25 to 35°C. Discontinuities in the concentration dependence of ultrasound velocity at two critical concentrations indicated a complex association pattern at each temperature. Micelle formation at concentrations between the two critical concentrations was accompanied, at all temperatures, by increases of the apparent molar volume and the apparent molar compressibility. Temperature increase caused linear increases in both the apparent molar volume and compressibility of chlorpromazine in the micellar form. © 1991.

引用

页码：316 / 320

页数：5

共 13 条

[1] OSMOTIC AND ACTIVITY-COEFFICIENTS OF AMPHIPHILIC DRUGS IN AQUEOUS-SOLUTION [J].

ATTWOOD, D ;

DICKINSON, NA ;

MOSQUERA, V ;

VILLAR, VP .

JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (15) :4203-4206

[2] A CALORIMETRIC STUDY ON THE SELF-ASSOCIATION OF AN AMPHIPHILIC PHENOTHIAZINE DRUG IN AQUEOUS-ELECTROLYTE SOLUTIONS [J].

ATTWOOD, D ;

FLETCHER, P ;

BOITARD, E ;

DUBES, JP ;

TACHOIRE, H .

JOURNAL OF PHYSICAL CHEMISTRY, 1990, 94 (15) :6034-6041

[3] ASSOCIATION MODELS FOR AN AMPHIPHILIC DRUG IN AQUEOUS-SOLUTIONS OF HIGH IONIC-STRENGTH FROM CALORIMETRIC STUDIES [J].

ATTWOOD, D ;

BOITARD, E ;

DUBES, JP ;

TACHOIRE, H .

COLLOIDS AND SURFACES, 1990, 48 (1-3) :35-46

[4] COMPLEX AGGREGATION PATTERNS FOR THE SELF-ASSOCIATION OF PHENOTHIAZINE DRUGS IN AQUEOUS-SOLUTION [J].

ATTWOOD, D ;

DOUGHTY, D ;

MOSQUERA, V ;

VILLAR, VP .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1991, 141 (02) :316-321

[5] THERMODYNAMIC PROPERTIES OF AMPHIPHILIC DRUGS IN AQUEOUS-SOLUTION [J].

ATTWOOD, D ;

MOSQUERA, V ;

VILLAR, VP .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1989, 85 :3011-3017

[6]

ATTWOOD D, 1989, SURFACTANTS SOLUTION, V7, P265

[7]

ATTWOOD D, 1983, SURFACTANT SYSTEMS, pCH4

[8] MICELLE FORMATION BY SOME PHENOTHIAZINE DERIVATIVES .2. NUCLEAR MAGNETIC RESONANCE STUDIES IN DEUTERIUM OXIDE [J].

FLORENCE, AT ;

PARFITT, RT .

JOURNAL OF PHYSICAL CHEMISTRY, 1971, 75 (23) :3554-&

[9] EFFECT OF TEMPERATURE AND UREA ON APPARENT MOLAL VOLUMES AND HEAT-CAPACITIES OF N-NONYLTRIMETHYLAMMONIUM BROMIDE IN WATER [J].

MUSBALLY, GM ;

PERRON, G ;

DESNOYERS, JE .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1976, 54 (01) :80-93

[10] PARTIAL MOLAL VOLUMES OF SURFACE ACTIVE AGENTS IN MICELLAR, SINGLY DISPERSED, AND HYDRATED SOLID STATES [J].

SHINODA, K ;

SODA, T .

JOURNAL OF PHYSICAL CHEMISTRY, 1963, 67 (10) :2072-&

← 1 2 →