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THE MEASUREMENT AND INTERPRETATION OF AGE-SPECIFIC VACCINE EFFICACY

被引：41
作者：
FARRINGTON, CP
机构：
[1] Communicable Disease Surveillance Centre, London, NW9 5EQ
来源：
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 1992年 / 21卷 / 05期
关键词：
D O I：
10.1093/ije/21.5.1014
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.
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页码：1014 / 1020
页数：7
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