EVIDENCE FOR A DISSOCIATION BETWEEN BENZODIAZEPINE WITHDRAWAL SIGNS

被引：21

作者：

GOUDIE, AJ

HARRISON, AA

LEATHLEY, MJ

机构：

[1] Department of Psychology, Liverpool University, Liverpool, L69 3BX, Eleanor Rathbone Building

[2] Department of Experimental Psychology, University of Cambridge, CB2 3EB, Downing St.

来源：

NEUROREPORT | 1993年 / 4卷 / 03期

关键词：

DEPENDENCE; WITHDRAWAL; BENZODIAZEPINES; CHLORDIAZEPOXIDE; WEIGHT LOSS; CONDITIONED TASTE AVERSION; RATS;

D O I：

10.1097/00001756-199303000-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE relationship between benzodiazepine-withdrawal induced weight loss and conditioned taste aversion was studied. Rats were treated with chlordiazepoxide (CDP) for 10 days (n = 37) or with vehicle (n = 39). Significant withdrawal-induced weight loss was observed. On day 11 all animals received an intra-oral infusion of saccharin. In a subsequent saccharin vs water choice test significant withdrawal-induced conditioned taste aversion was observed, as CDP pretreated animals drank less saccharin than controls. The two withdrawal indices were not correlated in the CDP pretreated animals [r = + 0.05], despite the fact that we studied a large group of rats. These data are in agreement with suggestions that drug withdrawal syndromes may be heterogeneous phenomena with a number of different underlying neural mechanisms.

引用

页码：295 / 298

页数：4

共 25 条

[1] ARE THERE CHANGES IN SENSITIVITY TO 5-HT3 RECEPTOR LIGANDS FOLLOWING CHRONIC DIAZEPAM TREATMENT [J].