POLYAMINES PREVENT DFMO-MEDIATED INHIBITION OF ANGIOGENESIS

被引：26

作者：

JASNIS, MA ^{[1
]}

KLEIN, S ^{[1
]}

MONTE, M ^{[1
]}

DAVEL, L ^{[1
]}

DELUSTIG, ES ^{[1
]}

ALGRANATI, ID ^{[1
]}

机构：

[1] FDN CAMPOMAR,INST INVEST BIOQUIM,BUENOS AIRES,DF,ARGENTINA

来源：

CANCER LETTERS | 1994年 / 79卷 / 01期

关键词：

TUMOR; ANGIOGENESIS; POLYAMINES; DFMO;

D O I：

10.1016/0304-3835(94)90060-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor growth mainly depend on formation of new blood vessels. DFMO (alpha-difluoromethylornithine), an inhibitor of polyamine biosynthesis, inhibits tumor growth in many animal tumors. Our investigation was to evaluate the requirement of polyamines for induction of angiogenesis by tumor cells and spleen lymphocytes from tumor-bearing mice. In this regard, we have added DFMO to cell cultures. The neovascular response induced either by tumor cells or spleen lymphocytes was completely abrogated. This inhibition could be reversed by the addition of exogenous putrescine. These findings suggest that the effect of DFMO on angiogenesis is, in part, mediated by the inhibition of polyamine biosynthesis.

引用

页码：39 / 43

页数：5

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