SURVIVAL OF FETAL NEURAL TISSUE FROM THE H-2K(B)-TSA58 TRANSGENIC MOUSE GRAFTED TO ADULT-MOUSE BRAIN

被引：4

作者：

KERSHAW, TR

SINDEN, JD

机构：

[1] Neurodegenerative Diseases Research Group, Department of Psychology, Institute of Psychiatry, London, SE5 8AF, Denmark Hill

来源：

CELL TRANSPLANTATION | 1993年 / 2卷 / 03期

关键词：

TRANSPLANTS; FETAL; TSA58; H-2K(B); TRANSGENIC;

D O I：

10.1177/096368979300200305

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Many recent studies have used a temperature sensitive strain of the simian virus 40 large tumor antigen gene (tsA58) to immortalise foetal neural cells by gene insertion in vitro. The H-2K(b)-tsA58 transgenic mouse circumvents the need for such genetic manipulation as the tsA58 gene is already within its genome. The results from this study show that foetal neural cells from this mouse do no proliferate and form tumors after grafting to adult brain; rather they survive and differentiate in a manner similar to nontransgenic foetal neural transplants. Therefore, this mouse is a potential source of cells for generating cell lines useful for transplantation studies.

引用

页码：215 / 222

页数：8

共 28 条

[1]

BJORKLUND A, 1983, ACTA PHYSIOL SCAND, P1

[2] TRANSGENIC MICE HARBORING SV40 T-ANTIGEN GENES DEVELOP CHARACTERISTIC BRAIN-TUMORS [J].

BRINSTER, RL ;

CHEN, HY ;

MESSING, A ;

VANDYKE, T ;

LEVINE, AJ ;

PALMITER, RD .

CELL, 1984, 37 (02) :367-379

[3] LOCALIZATION OF AN EPITOPE OF A MICROTUBULE-ASSOCIATED PROTEIN-1X IN OUTGROWING AXONS OF THE DEVELOPING RAT CENTRAL-NERVOUS-SYSTEM [J].

CALVERT, RA ;

WOODHAMS, PL ;

ANDERTON, BH .

NEUROSCIENCE, 1987, 23 (01) :131-141

[4] THE REGULATION AND EXPRESSION OF MHC CLASS-I GENES [J].

DAVID-WATINE, B ;

ISRAEL, A ;

KOURILSKY, P .

IMMUNOLOGY TODAY, 1990, 11 (08) :286-292

[5] ABNORMAL PERIKARYAL IMMUNOREACTIVITY TO THE PHOSPHORYLATED HEAVY NEUROFILAMENT UNIT IN INTRACEREBRAL BASAL FOREBRAIN TRANSPLANTS [J].

DOERING, LC ;

NILSSON, OG ;

AGUAYO, AJ .

EXPERIMENTAL NEUROLOGY, 1991, 111 (01) :1-8

[6] IMMORTAL RAT HIPPOCAMPAL CELL-LINES EXHIBIT NEURONAL AND GLIAL LINEAGES AND NEUROTROPHIN GENE-EXPRESSION [J].

EVES, EM ;

TUCKER, MS ;

ROBACK, JD ;

DOWNEN, M ;

ROSNER, MR ;

WAINER, BH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4373-4377

[7]

GRAY JA, 1990, SEMIN NEUROSCI, V2, P133

[8] EFFECTS OF CHOLINERGIC-RICH NEURAL GRAFTS ON RADIAL MAZE PERFORMANCE OF RATS AFTER EXCITOTOXIC LESIONS OF THE FOREBRAIN CHOLINERGIC PROJECTION SYSTEM .1. AMELIORATION OF COGNITIVE DEFICITS BY TRANSPLANTS INTO CORTEX AND HIPPOCAMPUS BUT NOT INTO BASAL FOREBRAIN [J].

HODGES, H ;

ALLEN, Y ;

KERSHAW, T ;

LANTOS, PL ;

GRAY, JA ;

SINDEN, J .

NEUROSCIENCE, 1991, 45 (03) :587-607

[9] CELL-LINES ESTABLISHED BY A TEMPERATURE-SENSITIVE SIMIAN VIRUS-40 LARGE-T-ANTIGEN GENE ARE GROWTH RESTRICTED AT THE NONPERMISSIVE TEMPERATURE [J].

JAT, PS ;

SHARP, PA .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (04) :1672-1681

[10] DIRECT DERIVATION OF CONDITIONALLY IMMORTAL CELL-LINES FROM AN H-2KB-TSA58 TRANSGENIC MOUSE [J].

JAT, PS ;

NOBLE, MD ;

ATALIOTIS, P ;

TANAKA, Y ;

YANNOUTSOS, N ;

LARSEN, L ;

KIOUSSIS, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5096-5100

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