ENDO-EXONUCLEASES - ENZYMES INVOLVED IN DNA-REPAIR AND CELL-DEATH

被引：22

作者：

FRASER, MJ

机构：

[1] Children's Leukaemia and Cancer Research Centre, University of New South Wales, Sydney, Randwick

来源：

BIOESSAYS | 1994年 / 16卷 / 10期

关键词：

D O I：

10.1002/bies.950161011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endo-exonucleases from E. coli to man, although very different proteins, are multifunctional enzymes with similar enzymatic activities. They probably have two common but opposing biological roles. On the one hand, they promote survival of the organism by acting in recombination and recombinational DNA repair to diversify and help preserve the genome intact. On the other hand, they degrade the genomic DNA when it is damaged beyond repair. This ensures elimination of heavily mutagenized cells from the population.

引用

页码：761 / 766

页数：6

共 51 条

[1]

ARENDS MJ, 1991, INT REV EXP PATHOL, V32, P223

[2] IDENTIFICATION OF DEOXYRIBONUCLEASE-II AS AN ENDONUCLEASE INVOLVED IN APOPTOSIS [J].