A SIMPLE METHOD FOR THE PROTECTION OF ARYL AMINES AS THEIR T-BUTYLCARBAMOYL (BOC) DERIVATIVES

被引：98

作者：

KELLY, TA

MCNEIL, DW

机构：

[1] Department of Medicinal Chemistry Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT 06877

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

关键词：

D O I：

10.1016/0040-4039(94)88411-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has been found that aryl amines can be directly protected as their Boc derivatives by treatment of the amine with two equivalents of NaHMDS in THF followed by one equivalent of di-t-butyldicarbonate. This procedure works on a wide variety of both electron-rich and electron-deficient aryl amines.

引用

页码：9003 / 9006

页数：4

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