FURTHER TOLYPORPHINS FROM THE BLUE-GREEN-ALGA TOLYPOTHRIX NODOSA

被引：48

作者：

PRINSEP, MR

PATTERSON, GML

LARSEN, LK

SMITH, CD

机构：

[1] UNIV HAWAII MANOA,DEPT CHEM,HONOLULU,HI 96822

[2] FOX CHASE CANC CTR,PHILADELPHIA,PA 19111

来源：

TETRAHEDRON | 1995年 / 51卷 / 38期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4020(95)00615-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.

引用

页码：10523 / 10530

页数：8

共 5 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].