COMPARATIVE EFFECTS OF TICRYNAFEN AND HYDROCHLOROTHIAZIDE ON BLOOD-PRESSURE, RENAL-FUNCTION, SERUM URIC-ACID AND ELECTROLYTES, AND BODY-FLUID SPACES IN HYPERTENSIVE MAN

被引：10

作者：

BAUER, JH ^{[1
]}

BROOKS, CS ^{[1
]}

机构：

[1] UNIV MISSOURI,MED CTR,DEPT MED,COLUMBIA,MO 65201

来源：

NEPHRON | 1979年 / 23卷

关键词：

D O I：

10.1159/000181670

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

25 hypertensive subjects underwent a double-blind, randomized study to compare the effects of ticrynafen (TCNF) with hydrochlorothiazide (HCTZ) on blood pressure (BP), renal function, serum uric acid (UA) and electrolytes, and body fluid spaces. BP was similarly lowered by TCNF and HCTZ. Neither TCNF nor HCTZ has a significant effect on true or regular creatinine, inulin, or PAH clearances. TCNF lowered UA, whereas HCTZ elevated UA. Both produced similar electrolyte disturbances. Neither TCNF nor HCTZ, according to our methods, had a significant effect on plasma volume, extracellular fluid, or total body water. The primary advantage of TCNF compared with HCTZ is its profound hypouricemic effect.

引用

页码：57 / 63

页数：7

共 33 条

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