LISURIDE AND LSD - DOPAMINERGIC AND SEROTONERGIC INTERACTIONS IN THE SEROTONIN SYNDROME

被引:46
作者
SILBERGELD, EK
HRUSKA, RE
机构
[1] Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, 20205, MD
关键词
Behavior; Dopamine; Ergots; Lisuride; LSD; Serotonin;
D O I
10.1007/BF00492209
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A characteristic behavioral syndrome has been associated with stimulation of central serotonin receptors in rats. This behavior can be produced by inhibition of monoamine oxidase and administration of 5-hydroxytryptophan as well as by direct acting serotonergic agonists. LSD and the novel ergot derivative lisuirde produced this syndrome in rats. These drugs possess both serotonergic and dopaminergic properties. Since changes in dopaminergic function have also been reported to affect the so-called serotonin syndrome, it was not clear how the two ergot drugs acted to produce this syndrome. The syndrome produced by pargyline and 5-hydroxytryptophan methyl ester was blocked by haloperidol, methysergide, parachlorophenylalanine, and alpha-methylparatyrosine; these treatments failed to block the effects of lisuride. Metoclopramide did not block the syndrome produced by either lisuride or pargyline plus 5-hydroxytryptophan methyl ester. Methysergide partially blocked the behavioral effects of LSD; pretreatment with either haloperidol or metoclopramide potentiated and prolonged the behavioral effects of LSD. The results suggest that dopaminergic modulation of the serotonin syndrome occurs before the serotonin receptor involved in this behavior. Also, the differences between LSD and lisuride may be relevant to their different psychopharmacological properties. © 1979 Springer-Verlag.
引用
收藏
页码:233 / 237
页数:5
相关论文
共 20 条
[1]  
DAPRADA M, 1977, NEUROSCI LETT, V6, P349, DOI 10.1016/0304-3940(77)90097-0
[2]   RELATIONSHIP OF BRAIN MONOAMINE AND LOCOMOTOR ACTIVITY IN RATS [J].
FOLDES, A .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (17) :1617-1621
[4]   ROLE OF BRAIN DOPAMINE IN HYPERACTIVITY SYNDROME PRODUCED BY INCREASED 5-HYDROXYTRYPTAMINE SYNTHESIS IN RATS [J].
GREEN, AR ;
GRAHAMES.DG .
NEUROPHARMACOLOGY, 1974, 13 (10-1) :949-959
[5]  
GREEN AR, 1976, NATURE, V260, P487
[6]   PERIPHERAL SEROTONIN ANTAGONISTS - FAILURE TO ANTAGONIZE SEROTONIN IN BRAIN AREAS RECEIVING A PROMINENT SEROTONERGIC INPUT [J].
HAIGLER, HJ ;
AGHAJANIAN, GK .
JOURNAL OF NEURAL TRANSMISSION, 1974, 35 (04) :257-273
[7]  
HOLLISTER AS, 1976, J PHARMACOL EXP THER, V198, P12
[8]   DIRECT DOPAMINERGIC ACTION OF LISURIDE HYDROGEN MALEATE, AN ERGOT DERIVATIVE, IN MICE [J].
HOROWSKI, R ;
WACHTEL, H .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 36 (02) :373-383
[9]   EVIDENCE FOR FUNCTIONAL INTERACTION OF 2 CENTRAL NEUROTRANSMITTERS [J].
JACOBS, BL .
PSYCHOPHARMACOLOGIA, 1974, 39 (01) :81-86
[10]   ANIMAL BEHAVIOR MODEL FOR STUDYING CENTRAL SEROTONERGIC SYNAPSES [J].
JACOBS, BL .
LIFE SCIENCES, 1976, 19 (06) :777-785