SIMPLE AND RAPID HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PAPAVERINE IN PLASMA

被引：15

作者：

PIERSON, SL

HANIGAN, JJ

TAYLOR, RE

MCCLURG, JE

机构：

[1] Biological Division, Harris Laboratories, Inc, Lincoln, Nebraska

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

High‐pressure liquid chromatography—‐analysis; papaverine in human plasma; bioavailability; Papaverine—analysis; high‐pressure liquid chromatography; human plasma; Relaxants (smooth muscle)—papaverine; high‐pressure liquid chromatographic analysis;

D O I：

10.1002/jps.2600681224

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid and sensitive high‐pressure liquid chromatographic (HPLC) assay is described for the quantification of papaverine in plasma. A paired‐ion, reversed‐phase system was employed with detection at 254 nm. This procedure yielded reproducible results with a sensitivity of 2 ng/ml. Total extraction and quantification time was < 1 hr. The suitability of this procedure for plasma sample analysis from a bioavailability study was demonstrated. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1550 / 1551

页数：2

共 11 条

[1]

ARNOLD JD, 1977, INT J CLIN PHARM BI, V15, P230

[2] DETERMINATION OF PAPAVERINE IN BLOOD-SAMPLES BY GAS-CHROMATOGRAPHY USING A FLAME-IONIZATION AND A NITROGENPHOSPHORUS DETECTOR [J].