TREATMENT OF EXPERIMENTAL SALMONELLA-TYPHIMURIUM INFECTION IN MICE WITH LOMEFLOXACIN

To evaluate the difluorinated quinolone lomefloxacin in murine typhoid, mice were inoculated intraperitoneally with the LT-2 strain of Salmonella typhimurium and treated with graded doses of the drug given once daily by an orogastric needle. Treatment with lomefloxacin for seven days reduced mortality with a 50% effective dose of 2·5-7·8 mg/kg/day. When given once daily for three days, doses {succeeds or equal to} 5 mg lomefloxacin/kg/day caused significant reductions in splenic counts of S. typhimurium and prevented the inflammatory response to infection in the spleen. © 1990 The British Society for Antimicrobial Chemotherapy.