FINE SPECIFICITY OF REGULATORY T-CELLS .4. IDIOTYPIC COMPLEMENTARITY AND ANTIGEN-BRIDGING INTERACTIONS IN THE ANTI-LYSOZYME RESPONSE

被引：80

作者：

ADORINI, L ^{[1
]}

HARVEY, M ^{[1
]}

SERCARZ, EE ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,COLL LETTERS & SCI,DEPT MICROBIOL,LOS ANGELES,CA 90024

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 11期

关键词：

D O I：

10.1002/eji.1830091113

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The hen egg‐white lysozyme (HEL)‐specific B cells which are activated in response to HEL share a cross‐reactive idiotype as well as submolecular specificity. Helper T cells of two different specificities are implicated in their optimal activation, one recognizing the idiotype and the other, an epitope on the HEL molecule opposite to the one recognized by B cells. Thus, efficient T‐B collaboration involves both idiotypic complementarity and antigen bridging. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：906 / 909

页数：4

共 19 条

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