LISTERICIDAL ACTIVITY OF HUMAN NEUTROPHIL CATHEPSIN-G

被引：20

作者：

ALFORD, CE ^{[1
]}

AMARAL, E ^{[1
]}

CAMPBELL, PA ^{[1
]}

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,1400 JACKSON ST,DENVER,CO 80206

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1990年 / 136卷

关键词：

D O I：

10.1099/00221287-136-6-997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate that cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule. The listericidal activity of cathepsin G occurred in a manner that was both time-dependent and concentration-dependent.

引用

页码：997 / 1000

页数：4

共 20 条

[1] BARRETT AJ, 1981, METHOD ENZYMOL, V80, P561
[2] CLARK J M, 1970, Infection and Immunity, V1, P607
[3] CZUPRYNSKI CJ, 1985, J IMMUNOL, V134, P3449
[4] CZUPRYNSKI CJ, 1984, J LEUKOCYTE BIOL, V35, P193
[5] DONOWITZ GR, 1983, ADV HOST DEFENSE MEC, V3, P55
[6] Elsbach P., 1988, INFLAMMATION BASIC P, P445
[7] ANTIBIOTIC PROTEINS OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES
GABAY, JE
SCOTT, RW
CAMPANELLI, D
GRIFFITH, J
WILDE, C
MARRA, MN
SEEGER, M
NATHAN, CF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5610 - 5614
[8] RECENT ADVANCES IN CHRONIC GRANULOMATOUS-DISEASE - DISCUSSION
GALLIN, JI
BUESCHER, ES
SELIGMANN, BE
NATH, J
GAITHER, T
KATZ, P
[J]. ANNALS OF INTERNAL MEDICINE, 1983, 99 (05) : 657 - 674
[9] RELATIONSHIPS BETWEEN OXIDATIVE-METABOLISM, MACROPHAGE ACTIVATION, AND ANTILISTERIAL ACTIVITY
GODFREY, RW
WILDER, MS
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1984, 36 (04) : 533 - 543
[10] HIRSCHJG, 1980, J EXP MED, V111, P323

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