5,7-DHT FACILITATED LORDOSIS - EFFECTS OF 5-HT AGONISTS

被引：36

作者：

AIELLOZALDIVAR, M

LUINE, V

FRANKFURT, M

机构：

[1] CUNY HUNTER COLL, DEPT PSYCHOL,695 PK AVE, NEW YORK, NY 10021 USA

[2] ROCKEFELLER UNIV, NEUROENDOCRINOL LAB, NEW YORK, NY 10021 USA

来源：

NEUROREPORT | 1992年 / 3卷 / 06期

关键词：

LORDOSIS; SEROTONIN (5-HT); 5,7-DIHYDROXYTRYPTAMINE (5,7-DHT); 8-HYDROXY-2-(DI-N-PROPYLAMINO) TETRALIN (8-OH-DPAT); 1-(M-TRIFLUOROMETHYLPHENYL) PIPERAZINE (TFMPP); HYPOTHALAMIC VENTROMEDIAL NUCLEUS (VMN); MEDIAL PREOPTIC NUCLEUS (MPOA);

D O I：

10.1097/00001756-199206000-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE role of 5-HT (serotonin) in regulating lordosis was investigated by combining peripheral administration of the 5-HT agonists 8-OH-DPAT (8-hydroxy-2-[di-N-propylamino]tetralin) or TFMPP (1-[m-trifluoromethylphenyl] piperazine), with intrahypothalamic application of the 5-HT neurotoxin 5,7-DHT (5,7-dihydroxytryptamine). The 5-HT1A agonist, 8-OH-DPAT, significantly inhibited lordosis in 5,7-DHT-treated and non-treated rats. TFMPP, an agonist at 5-HT1B and 5-HT1C receptors, significantly facilitated lordosis in 5,7-DHT-treated and non-treated rats. Our results show that both inhibitory and facilitatory influences of hypothalamic 5-HT on lordosis, are modulated via postsynaptic receptors.

引用

页码：542 / 544

页数：3

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