STIMULATION OF GLYCOLYTIC KEY ENZYMES IN CEREBRAL-CORTEX BY INSULIN

被引：41

作者：

HOYER, S ^{[1
]}

PREM, L ^{[1
]}

SORBI, S ^{[1
]}

AMADUCCI, L ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT NEUROL,I-5013 FLORENCE,ITALY

来源：

NEUROREPORT | 1993年 / 4卷 / 07期

关键词：

INSULIN; BRAIN; HEXOKINASE; PHOSPHOFRUCTOKINASE; METABOLIC CONTROL;

D O I：

10.1097/00001756-199307000-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IN adult male Wistar rats, a test was conducted to find whether or not insulin, administered intracerebroventricularly, would stimulate the activities of the glycolytic key enzymes hexokinase and phosphofructokinase in brain tissue as in non-neuronal tissue. The data clearly demonstrated an increase in these enzyme activities in cerebral cortex by approximately 20% after 80 mU insulin, whereas the increase in the hippocampus was just short of statistical significance. It is concluded that insulin controls glycolytic flux in the brain, and the suggestion that any perturbation in insulin signal transduction has severe impacts on brain glucose metabolism seems justified.

引用

页码：991 / 993

页数：3

共 28 条

[1] INSULIN AND INSULIN-LIKE GROWTH-FACTOR RECEPTORS IN THE NERVOUS-SYSTEM [J].