THE PROTEIN TYROSINE KINASE, FYN, IN ALZHEIMERS-DISEASE PATHOLOGY

被引：116

作者：

SHIRAZI, SK ^{[1
]}

WOOD, JG ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT ANAT & CELL BIOL,ATLANTA,GA 30322

来源：

NEUROREPORT | 1993年 / 4卷 / 04期

关键词：

ALZHEIMERS DISEASE; FYN; TYROSINE KINASE;

D O I：

10.1097/00001756-199304000-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IMMUNOHISTOCHEMISTRY was used to assess the distribution of protein tyrosine kinases in Alzheimer's disease (AD) pathology. One of these, fyn, exhibited an interesting pattern of immunoreactivity. Low levels of immunoreactivity were apparent in neurons from both normal and AD brain. However a subset of neurons in AD brain exhibited intense fyn immunoreactivity. Double label immunohistochemistry revealed that fyn-positive neurons were also positive for abnormally phosphorylated microtubule-associated protein, tau. Proline-directed kinases, whose activity is regulated by phosphorylation on tyrosine, may be responsible for abnormal tau phosphorylation. These results identify fyn as a candidate kinase for regulating putative proline-directed kinases involved in abnormal tau phosphorylation.

引用

页码：435 / 437

页数：3

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