EVIDENCE FOR SELECTIVE RELEASE OF RODENT ISLET AMYLOID POLYPEPTIDE THROUGH THE CONSTITUTIVE SECRETORY PATHWAY

被引：37

作者：

KAHN, SE ^{[1
]}

VERCHERE, CB ^{[1
]}

DALESSIO, DA ^{[1
]}

COOK, DL ^{[1
]}

FUJIMOTO, WY ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT MED,DIV METAB ENDOCRINOL & NUTR,SEATTLE,WA 98195

来源：

DIABETOLOGIA | 1993年 / 36卷 / 06期

关键词：

INSULIN; SECRETION; PANCREAS; AMYLOID; INSULINOMAS;

D O I：

10.1007/BF02743276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine the potential for differential release of islet amyloid polypeptide and insulin, we performed studies in Tat islet monolayer cultures under conditions known to impair regulated beta-cell secretion. In inhibiting concentrations of epinephrine or the absence of calcium, islet amyloid polypeptide was secreted through a constitutive pathway while insulin was not. These findings suggest a mechanism for persistent islet amyloid polypeptide secretion and amyloid accumulation when regulated insulin release is impaired as in Type 2 (non-insulin-dependent) diabetes mellitus and insulinomas.

引用

页码：570 / 573

页数：4

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