SYNTHESIS OF NEW IMIDAZO[1,2-B]PYRIDAZINE ISOSTERES OF POTENT IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II ANTAGONISTS

被引：8

作者：

WALSH, TF ^{[1
]}

FITCH, KJ ^{[1
]}

MACCOSS, M ^{[1
]}

CHANG, RSL ^{[1
]}

KIVLIGHN, SD ^{[1
]}

LOTTI, VJ ^{[1
]}

SIEGL, PKS ^{[1
]}

PATCHETT, AA ^{[1
]}

GREENLEE, WJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)81150-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a new class of angiotensin II receptor antagonists bearing a substituted imidazo[1,2-b]pyridazine moiety, and the evaluation of these compounds as isosteric replacements for potent imidazo[4,5-b]pyridine based antagonists is presented.

引用

页码：219 / 222

页数：4

共 13 条

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