CD31, CD62E, AND CD62P IDENTIFY A SPECIFIC PATTERN OF ENDOTHELIAL ACTIVATION IN GRAVES-DISEASE

被引：3

作者：

AUBERT, VD

BENE, MC

LECLERE, J

FAURE, GC

机构：

[1] FAC MED NANCY,IMMUNOL LAB,NANCY,FRANCE

[2] CHU NANCY,NANCY,FRANCE

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 76卷 / 02期

关键词：

D O I：

10.1006/clin.1995.1112

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The different degrees of lymphocytic infiltration observed in Graves' disease, Hashimoto's disease, and De Quervain thyroiditis suggest that the regulation of adhesion molecules expressed on endothelial cells could be different in these autoimmune disorders of the thyroid. Using immunohistological techniques, we observed that thyroid samples from patients with Graves' disease displayed a characteristic pattern of capillary proliferation, with CD62P, CD62E, and CD31 expression on endothelial cells. This was different from the pattern and size of endothelial cells expressing adhesion molecules in the two other types of thyroiditis where larger vessels and high endothelial venules were stained. Almost no signs of endothelial cell activation could be seen in a comparative series of non-autoimmune disorders. (C) 1995 Academic Press, Inc.

引用

页码：170 / 179

页数：10

共 28 条

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