MELATONIN IMPROVES EVENING NAPPING

被引：67

作者：

NAVE, R ^{[1
]}

PELED, R ^{[1
]}

LAVIE, P ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,BRUCE RAPPAPORT FAC MED,SLEEP LAB,IL-32000 HAIFA,ISRAEL

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 275卷 / 02期

关键词：

NAPPING; POLYSOMNOGRAPHIC RECORDING; MELATONIN;

D O I：

10.1016/0014-2999(94)00769-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Twelve young adults were treated with either melatonin, 3 mg or 6 mg, or placebo, at two different times before an early evening nap (18.00-20.00 h) according to a balanced double-blind Latin square design. Polysomnographic monitoring revealed that both dosages of melatonin significantly shortened sleep latency and increased total sleep time in comparison to placebo, irrespective of the time of administration. Subjects also tended to assess their sleep as 'deeper' after melatonin treatment. Based on previous data and the present results, it was concluded that exogenous melatonin exerts hypnotic effects only when circulating levels of endogenous melatonin are low.

引用

页码：213 / 216

页数：4

共 18 条

[1] EFFECT OF MELATONIN UPON HUMAN BRAIN - ITS POSSIBLE THERAPEUTIC IMPLICATIONS [J].

ANTONTAY, F ;

DIAZ, JL ;

FERNANDE.A .

LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY, 1971, 10 (15) :841-&

[2] SOME EFFECTS OF JET-LAG AND THEIR ALLEVIATION BY MELATONIN [J].

ARENDT, J ;

ALDHOUS, M ;

ENGLISH, J ;

MARKS, V ;

ARENDT, JH ;

MARKS, M ;

FOLKARD, S .

ERGONOMICS, 1987, 30 (09) :1379-1393

[3] THE EFFECTS OF CHRONIC, SMALL DOSES OF MELATONIN GIVEN IN THE LATE AFTERNOON ON FATIGUE IN MAN - A PRELIMINARY-STUDY [J].

ARENDT, J ;

BORBELY, AA ;

FRANEY, C ;

WRIGHT, J .

NEUROSCIENCE LETTERS, 1984, 45 (03) :317-321

[4]

ARENDT J, 1985, CIBA F SYMP, V117, P266

[5] MELATONIN AND SLEEP IN HUMANS [J].

DAWSON, D ;

ENCEL, N .

JOURNAL OF PINEAL RESEARCH, 1993, 15 (01) :1-12

[6] EFFECT OF INDUCING NOCTURNAL SERUM MELATONIN CONCENTRATIONS IN DAYTIME ON SLEEP, MOOD, BODY-TEMPERATURE, AND PERFORMANCE [J].

DOLLINS, AB ;

ZHDANOVA, IV ;

WURTMAN, RJ ;

LYNCH, HJ ;

DENG, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) :1824-1828

[7]

HAIMOV I, 1993, SLEEP RES, V22, P205

[8]

Hughes Rod J., 1994, Journal of Sleep Research, V3, P111

[9]

JAMES SP, 1990, NEUROPSYCHOPHARMACOL, V3, P19

[10] THE EFFECT OF MELATONIN ON NORMAL SLEEP [J].

JAMES, SP ;

MENDELSON, WB ;

SACK, DA ;

ROSENTHAL, NE ;

WEHR, TA .

NEUROPSYCHOPHARMACOLOGY, 1987, 1 (01) :41-44

← 1 2 →