DEVELOPMENT OF RESISTANCE TO ACTIVATED PROTEIN-C DURING PREGNANCY

被引：191

作者：

CUMMING, AM ^{[1
]}

TAIT, RC ^{[1
]}

FILDES, S ^{[1
]}

YOONG, A ^{[1
]}

KEENEY, S ^{[1
]}

HAY, CRM ^{[1
]}

机构：

[1] ST MARYS HOSP,DEPT OBSTET & GYNAECOL,MANCHESTER M13 0JH,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 03期

关键词：

APC RESISTANCE; PREGNANCY; THROMBOPHILIA; FACTOR V LEIDEN; THROMBOSIS RISK FACTORS;

D O I：

10.1111/j.1365-2141.1995.tb05610.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We measured activated protein C (APC) anti-coagulant activity in 20 healthy women at 14-20, 28 and 36 weeks gestation, and at 1 d post-partum. Significant reductions in the mean APC sensitivity ratio (APC-SR) were observed at all stages of pregnancy studied compared with the mean APC-SR obtained for baseline measurements carried out at > 8 weeks post-partum. APC resistance was seen in 8/19 (42%) and in 11/20 (55%) women at 14-20 and 28 weeks gestation respectively. The development of resistance to APC may contribute to the increased risk of thrombosis during pregnancy.

引用

页码：725 / 727

页数：3

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