DOUBLE-BLIND CONTROLLED TRIAL OF A MICRONIZED PREPARATION OF FLUMEDROXONE (DEMIGRAN) IN PROPHYLAXIS OF MIGRAINE

被引：19

作者：

BRADLEY, WG

HUDGSON, P

FOSTER, JB

NEWELL, DJ

机构：

[1] Regional Neurological Centre, Newcastle General Hospital, Nuffield Department of Industrial Health, University of New-castle upon Tyne

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1968年 / 3卷 / 5617期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1136/bmj.3.5617.531

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A double-blind cross-over trial of a micronized preparation of flumedroxone an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation fiumedroxone resulted in statistically fewer headaches of less severity. With the dose used in this trial (micronized flumedroxone 10 mg. t.d.s.) side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age. © 1968, British Medical Journal Publishing Group. All rights reserved.

引用

页码：531 / +

页数：1

共 12 条

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