AN AUTOMATED APPARATUS FOR DISSOLUTION STUDIES

被引：24

作者：

RICHTER, A

MYHRE, B

KHANNA, SC

机构：

[1] Pharmaceutical Research Department, Basle

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08281.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An automated apparatus for dissolution rate studies of solid dosage forms under sink conditions at constant volume has been developed. Sink condition was maintained in the small volume of the buffer by continuous elimination of the solution and replacement with fresh buffer. A mathematical treatment of the dissolution‐dilution system for the apparatus is given. The validity of the calculations has been proved using clomipramine solution and tablets. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：409 / &

共 4 条

[1]

HERSEY JA, 1968, BRIT PHARM C

[2] TABLET DISINTEGRATION AND PHYSIOLOGICAL AVAILABILITY OF DRUGS [J].