BIOSYNTHESIS OF SALSOLINOL, A TETRAHYDROISOQUINOLINE ALKALOID, IN HEALTHY-SUBJECTS

被引:62
作者
DOSTERT, P [1 ]
BENEDETTI, MS [1 ]
BELLOTTI, V [1 ]
ALLIEVI, C [1 ]
DORDAIN, G [1 ]
机构
[1] HOP NORD CLERMONT FERRAND,SERV NEUROL,CLERMONT FERRAND,FRANCE
关键词
1,2-dehydrosalsolinol; dopamine; pyruvic acid; Salsolinol biosynthesis in humans;
D O I
10.1007/BF01245043
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The R enantiomer of salsolinol was detected in the urine of two out of six healthy subjects, whereas 1,2-dehydrosalsolinol was present in the urine of all the subjects. (S)-salsolinol was never detected. Administration of Madopar for 7 days resulted in the presence of large amounts of (R)- and (S)-salsolinol in the urine of five out of the six subjects, the urinary excretion of 1,2-dehydrosalsolinol being generally not markedly increased. The presence of 1,2-dehydrosalsolinol in urine suggests that the biosynthesis of salsolinol in healthy volunteers should occur by condensation of dopamine with pyruvic acid, in keeping with Hahn's hypothesis. The absence of salsolinol in the urine of one subject after Madopar administration seems to indicate that the biological system(s) involved in the reduction of the C = N bond in 1,2-dehydrosalsolinol can be missing or not, or poorly, functional in some individuals, and suggests that there is no alternative pathway for the formation of salsolinol in healthy volunteers. © 1990 Springer-Verlag.
引用
收藏
页码:215 / 223
页数:9
相关论文
共 20 条