GLYCINE CLEAVAGE SYSTEM IN ASTROCYTES

被引：70

作者：

SATO, K

YOSHIDA, S

FUJIWARA, K

TADA, K

TOHYAMA, M

机构：

[1] OSAKA UNIV,BIOCHEM RES CTR,DEPT NEUROANAT,OSAKA,JAPAN

[2] UNIV TOKUSHIMA,SCH MED,INST ENZYME RES,TOKUSHIMA 770,JAPAN

[3] TOHOKU UNIV,SCH MED,DEPT PEDIAT,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 567卷 / 01期

关键词：

GLYCINE; GLYCINE CLEAVAGE SYSTEM; P-PROTEIN; ASTROCYTE; NONKETOTIC HYPERGLYCINEMIA;

D O I：

10.1016/0006-8993(91)91436-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest staining being noted in the hippocampus, the cerebellar cortex, the Bergmann glia in the cerebellum and the Muller cells in the retina. The weakest staining was seen in the brainstem and spinal cord. P-protein was found to be located in the mitochondria by an ultrastructural study.

引用

页码：64 / 70

页数：7

共 31 条

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[3]

CURTIS DR, 1968, EXP BRAIN RES, V6, P1

[4]

DAHL D, 1986, ASTROCYTES, V3, P1